Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 420611
Title Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study
Author(s) Hoevenaar-Blom, M.P.; Spijkerman, A.M.W.; Kromhout, D.; Berg, J.F. van den; Verschuren, M.W.W.
Source Sleep 34 (2011)11. - ISSN 0161-8105 - p. 1487 - 1492.
DOI http://dx.doi.org/10.5665/sleep.1382
Department(s) Chair Nutrition and Disease
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) coronary-heart-disease - whitehall-ii cohort - follow-up - population - mortality - women - risk - hypertension - events - associations
Abstract Study Objectives: We studied sleep duration and sleep quality in relation to cardiovascular disease (CVD) incidence. Design/Setting: Dutch population-based cohort study. Participants: 20,432 men and women aged 20-65 y with no history of CVD. Interventions: N/A Measurements: Sleep duration and sleep quality were assessed by a self-administered questionnaire. Morbidity data, vital status, and causes of death were obtained through linkage with several national registries. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated using Cox proportional hazards models. Results: During 10-15 years of follow-up, 1,486 CVD and 1,148 coronary heart disease (CHD) events occurred. Short sleepers (= 6 h) had a 15% higher risk of total CVD (HR: 1.15; 95%CI: 1.00-1.32) and a 23% higher risk of CHD (HR: 1.23 [1.04-1.45]) compared to normal sleepers (7 h) after adjustment for all confounders. Additional adjustment for intermediate biological risk factors attenuated these relative risks to 1.11 (0.97-1.27) for total CVD and to 1.19 (1.00-1.40) for CHD. Short sleepers with poor sleep quality had a 63% higher risk of CVD (HR: 1.63 [1.21-2.19]) and a 79% higher risk of CHD incidence (HR: 1.79 [1.24-2.58]) compared to normal sleepers with good sleep quality, after adjustments for all confounders. We observed no associations between long sleep duration (= 9 h) and CVD or CHD incidence. Conclusions: Short sleepers, especially those with poor sleep quality, have an increased risk of total CVD and CHD incidence. Future investigations should not only focus on sleep duration, but should also take sleep quality into account.
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