Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 421362
Title The effect of plant sterols on serum triglyceride concentrations is dependent on baseline concentrations: a pooled analysis of 12 randomised controlled trials
Author(s) Demonty, I.; Ras, R.T.; Knaap, H.C.M. van der; Meijer, L.; Zock, P.L.; Geleijnse, J.M.; Trautwein, E.A.
Source European Journal of Nutrition 52 (2013)1. - ISSN 1436-6207 - p. 153 - 160.
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) ldl-cholesterol concentrations - mildly hypercholesterolemic subjects - density-lipoprotein cholesterol - enriched spread - cardiovascular-disease - phytosterol intake - clinical-trials - plasma-lipids - fat spreads - diet
Abstract Purpose - Plant sterols (PS) are well known for their low-density lipoprotein cholesterol-lowering effect. Until recently, they were believed to have little or no impact on blood triglycerides (TG). However, studies taken individually were possibly lacking statistical power to detect modest TG decreases. This study was performed to quantify the TG-lowering effect of PS by pooling individual subject data from 12 randomised controlled trials that investigated the effects of PS on blood lipids. Methods - The main outcome variable was the control-adjusted PS effect on relative (%) and absolute (mmol/L) changes in TG. The relative and absolute changes in high-density lipoprotein cholesterol (HDL-C) were also assessed. Differences in changes of serum lipid concentrations between PS and control treatments were estimated by an ANCOVA using a random effect model which included PS intake (active or control), study and predefined subject characteristics. Results - The twelve randomised controlled trials included in total 935 hypercholesterolaemic subjects not preselected based on their baseline TG concentrations. In most studies, the PS dose ranged between 1.6 and 2.5 g/day. PS intake significantly lowered serum TG by 6.0% (95% CI: -10.7, -1.2) or 0.12 mmol/L (95% CI: -0.20, -0.04). No significant interaction was observed between PS intake and baseline TG concentrations on relative changes, but, on absolute changes, interaction was significant with larger TG decreases observed with higher TG concentrations at baseline. No effects were observed on HDL-C concentrations. Conclusions - These results show that PS exert a modest TG-lowering effect which is dependent on baseline concentrations.
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