Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 421810
Title Sensitivity of humoral immune parameters of poultry to minor macro- and micronutrient differences in two nutritionally complete layer feeds
Author(s) Adriaansen-Tennekes, R.; Vries Reilingh, G. de; Nieuwland, M.G.B.; Pieters, R.H.H.; Loveren, H. van; Huber, M.; Hoogenboom, R.; Parmentier, H.K.; Savelkoul, H.F.J.
Source Biological Agriculture and Horticulture 27 (2011)3-4. - ISSN 0144-8765 - p. 241 - 260.
Department(s) Cell Biology and Immunology
Adaptation Physiology
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) red-blood-cells - polyunsaturated fatty-acids - sugar-cane extract - antibody-responses - broiler-chickens - carcass characteristics - growth-performance - finishing steers - trace-elements - human health
Abstract The effect of differences in the composition of nutrients of two nutritionally complete layer diets on parameters from innate and adaptive immunity of chickens were examined. The diets were based on ingredients grown either organically or conventionally. As individual differences in nutrient sensitivity have been reported and as the immune system was used as a sensory organ to detect possible effects, layer hens divergently selected for high and low specific antibody (Ab) responses to SRBC, i.e. low line hens and high line hens, reflecting a genetically based differential immune competence were used. The parental line of these hens was randomly bred as the control line, and was used as well. To examine maternal and/or epigenetic effects on nutrient sensitivity, two subsequent generations were studied. In addition, the second generation was challenged with keyhole limpet haemocyanin (KLH). The most pronounced dietary effects were found in the low line birds of the first generation: specific Ab titres to NCD vaccine were significantly elevated in one of the two diets. In the second generation, significant differences were found in Ab and complement responses to the KLH inoculation. Immune competence of the selection lines was not affected. In the second generation control line hens showed the most pronounced effects of dietary treatment in immune responsiveness, with significant effects on specific Ab vaccine titres as well as in innate parameters. The results suggest that small nutritional differences due to the use of different sources of raw ingredients have immunomodulatory effects on innate and adaptive humoral immune parameters. The data indicate the importance of dietary components displaying the capacity to modulate the immune system.
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