Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 422533
Title A comparative in vitro study of the effects of separate and combined products of citrus e fructibus and cydonia e fructibus on immunological parameters of seasonal allergic rhinitis
Author(s) Baars, E.W.; Jong, M.C.; Boers, I.; Nierop, A.F.M.; Savelkoul, H.F.J.
Source Mediators of Inflammation 2012 (2012). - ISSN 0962-9351 - 8 p.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) mast-cells - cytokine production - histamine-release - responses - proliferation - flavonoids - gencydo(r)
Abstract This paper examined the effects of the combined product, Citrus e fructibus/Cydonia e fructibus (Citrus/Cydonia; Citrus and Cydonia: each 0.01¿g/mL), and separate products of Citrus (0.01¿g/mL) and Cydonia (0.01¿g/mL) on the immunological pathways involved in seasonal allergic rhinitis (SAR). Peripheral blood mononuclear cells (PBMCs) from five healthy and five grass pollen-allergic donors were isolated and analyzed in vitro after polyclonal and allergen-specific stimulation of T cells in the presence of the three extracts. The analyses demonstrated acceptable cell survival with no signs of toxicity. Citrus mainly had a selective effect on reducing allergen-specific chronic inflammatory (TNF-a; Citrus compared to Cydonia and Citrus/Cydonia: -87.4 (P <0.001) and -68.0 (P <0.05), resp.) and Th2 pathway activity (IL-5; Citrus compared to Cydonia: -217.8 (P <0.01); while, both Cydonia and Citrus/Cydonia mainly affected the induction of the allergen-specific Th1 pathway (IFN-¿; Cydonia and Citrus/Cydonia compared to Citrus: 3.8 (P <0.01) and 3.0 (P <0.01), resp.). Citrus and Cydonia demonstrated different working mechanisms in the treatment of SAR and the combination product did not demonstrate larger effects than the separate preparations. Further effectiveness and efficacy studies comparing the effects of the products on SAR in vivo are indicated.
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