Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 423119
Title The cross-sectional association between insulin resistance and circulating complement C3 is partly explained by plasma alanine aminotransferase, independent of central obesity and general inflammation (the CODAM study)
Author(s) Greevenbroek, M.M.J. van; Jacobs, M.; Kallen, C.J.H. van der; Vermeulen, V.M.M.J.; Jansen, E.H.J.M.; Schalkwijk, C.G.; Ferreira, I.; Feskens, E.J.M.; Stehouwer, C.D.A.
Source European Journal of Clinical Investigation 41 (2011)4. - ISSN 0014-2972 - p. 372 - 379.
Department(s) Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) fatty liver-disease - population-based cohort - myocardial-infarction - metabolic syndrome - risk-factor - serum c3 - nonalcoholic steatohepatitis - endothelial-cells - reactive protein - component-3
Abstract P>Background Complement C3, a central component of the innate immune system is increased in subjects with obesity and type 2 diabetes and is a novel risk factor for cardiovascular disease. We hypothesized that the strong association between insulin resistance and circulating amounts of C3 may be related to hepatic fat accumulation -independent of central obesity itself and of a general low-grade inflammatory response. Research question To what extent is the association between insulin resistance and C3 explained by plasma levels of alanine aminotransferase (ALT) as a surrogate of hepatic fat accumulation. Methods Cross-sectional analyses conducted in the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study. Analyses were restricted to subjects with none-to-moderate alcohol consumption (n = 453, 61 center dot 4% men). Multiple linear regression analyses were used to investigate the association between HOMA2IR (main determinant) and circulating complement C3 (main outcome), and the mediating role of ALT herein. All analyses were adjusted for age, sex, presence of type 2 diabetes mellitus or heart disease, use of medication, smoking, alcohol consumption, waist circumference and inflammation. Results Insulin resistance (estimated as HOMA2IR) was strongly associated with circulating C3 (standardized regression coefficient beta 0 center dot 40 [95% CI: 0 center dot 30; 0 center dot 49]) and also with ALT (beta 0 center dot 44 [0 center dot 34; 0 center dot 54]), both adjusted for the above-mentioned covariates. The association between HOMA2IR and C3 was attenuated after further adjustment for ALT (beta decreased to 0 center dot 34 [0 center dot 24; 0 center dot 44]). Concluding Remarks Plasma ALT can explain 14 center dot 2% of the strong association between insulin resistance and circulating concentrations of complement C3, independent of central obesity and general inflammation.
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