Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 423471
Title Genomic associations with somatic cell score in first-lactation Holstein cows
Author(s) Wijga, S.; Bastiaansen, J.W.M.; Wall, E.; Strandberg, E.; Haas, Y. de
Source Journal of Dairy Science 95 (2012)2. - ISSN 0022-0302 - p. 899 - 908.
DOI https://doi.org/10.3168/jds.2011-4717
Department(s) Animal Breeding and Genetics
LR - Backoffice
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) quantitative trait loci - affecting clinical mastitis - dairy-cattle breeds - 1st 3 lactations - milk-production - genetic-parameters - escherichia-coli - wide association - health traits - count traits
Abstract This genome-wide association study aimed to identify loci associated with lactation-average somatic cell score (LASCS) and the standard deviation of test-day somatic cell score (SCS-SD). It is one of the first studies to combine detailed phenotypic and genotypic cow data from research dairy herds located in different countries. The combined data set contained up to 52 individual test-days per lactation and thereby aimed to capture temporary increases in somatic cell score associated with infection. Phenotypic data for analysis consisted of 46,882 test-day records on 1,484 cows, and genotypic data consisted of 37,590 single nucleotide polymorphisms (SNP). Using an animal model, the associations between each individual SNP and the phenotypic data were estimated. To account for the risk of false positives, a false discovery rate threshold of 0.20 was set. The analyses showed that LASCS was significantly associated with a SNP on Bos taurus autosome (BTA) 4 and a SNP on BTA18. Likewise, SCS-SD was associated with this SNP on BTA18. In addition, SCS-SD significantly associated with a SNP on BTA6. Relatively few associations were found, suggesting that LASCS and SCS-SD are controlled by multiple loci distributed across the genome, each with a relatively small effect. Increased knowledge on genetic regulation of LASCS and SCS-SD may aid in identification of genes that play a role in mastitis resistance. Such knowledge helps us understand the genetic mechanisms leading to mastitis and in discovery of targets for mastitis therapeutics.
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