Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 423566
Title Programmable bacterial catalysis – designing cells for biosynthesis of value-added compounds
Author(s) Lam, M.C.; Suarez Diez, M.; Godinho, M.; Martins Dos Santos, V.A.P.
Source FEBS Letters 586 (2012)15. - ISSN 0014-5793 - p. 2184 - 2190.
DOI https://doi.org/10.1016/j.febslet.2012.02.030
Department(s) Systems and Synthetic Biology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) pseudomonas-putida kt2440 - recombinant escherichia-coli - genome-reduced bacterium - bacillus-subtilis - computational design - synthetic biology - model protocell - protein - pathway - metabolism
Abstract Bacteria have long been used for the synthesis of a wide range of useful proteins and compounds. The developments of new bioprocesses and improvements of existing strategies for syntheses of valuable products in various bacterial cell hosts have their own challenges and limitations. The field of synthetic biology has combined knowledge from different science and engineering disciplines and facilitated the advancement of novel biological components which has inspired the design of targeted biosynthesis. Here we discuss recent advances in synthetic biology with relevance to biosynthesis in bacteria and the applications of computational algorithms and tools for manipulation of cellular components. Continuous improvements are necessary to keep up with increasing demands in terms of complexity, scale, and predictability of biosynthesis products
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