Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 423582
Title Metabolic engineering of Rhizopus oryzae for the production of platform chemicals
Author(s) Meussen, B.J.; Graaff, L.H. de; Sanders, J.P.M.; Weusthuis, R.A.
Source Applied Microbiology and Biotechnology 94 (2012)4. - ISSN 0175-7598 - p. 875 - 886.
Department(s) Systems and Synthetic Biology
Biobased Chemistry and Technology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) lactic-acid production - lactate-dehydrogenase genes - zygomycete absidia-glauca - double-stranded-rna - l(+)-lactic acid - fumaric-acid - plasmid dna - homologous recombination - saccharomyces-cerevisiae - pyruvate-carboxylase
Abstract Rhizopus oryzae is a filamentous fungus belonging to the Zygomycetes. It is among others known for its ability to produce the sustainable platform chemicals L-(+)-lactic acid, fumaric acid, and ethanol. During glycolysis, all fermentable carbon sources are metabolized to pyruvate and subsequently distributed over the pathways leading to the formation of these products. These platform chemicals are produced in high yields on a wide range of carbon sources. The yields are in excess of 85 % of the theoretical yield for L-(+)-lactic acid and ethanol and over 65 % for fumaric acid. The study and optimization of the metabolic pathways involved in the production of these compounds requires well-developed metabolic engineering tools and knowledge of the genetic makeup of this organism. This review focuses on the current metabolic engineering techniques available for R. oryzae and their application on the metabolic pathways of the main fermentation products
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