Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 423981
Title Selenium status in adult cats and dogs fed high levels of dietary inorganic and organic selenium
Author(s) Todd, S.E.; Thomas, D.G.; Bosch, G.; Hendriks, W.H.
Source Journal of Animal Science 90 (2012)8. - ISSN 0021-8812 - p. 2549 - 2555.
DOI http://dx.doi.org/10.2527/jas.2011-3911
Department(s) Animal Nutrition
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) brush-border membrane - pet foods - absorption - selenate - liver - rat - se
Abstract Cats maintain higher blood Se concentrations compared to dogs and, unlike dogs, show no signs of chronic Se toxicity (selenosis) when fed dietary organic Se (selenomethionine) concentrations of 10 µg/g DM. This study investigated the response of cats and dogs to high dietary concentrations of sodium selenite and organic Se to determine differences in metabolism between both species. In 2 consecutive studies, 18 adult cats and 18 adult dogs of equal sex were fed a control diet (0.6 µg Se/g DM) or the control diet supplemented to 8 to 10 µg Se/g DM from Na2SeO3 or organic Se for 3 wk. All animals were fed the control diet 1 mo before the start of the study and blood samples were taken on d 0 and 21. The Se balance was assessed during the final week and a liver biopsy was obtained on the final day of the study. Measurements included plasma Se concentrations, plasma glutathione peroxidise (GPx) activities, plasma Se clearance, Se intake, and urinary Se excretion. No clinical signs of selenosis were observed in the cats or dogs, and apart from Se clearance, form of Se had no effect on any of the measurements. Apparent fecal Se absorption was greater in the dogs fed both forms of Se, while greater plasma Se concentrations were observed in the cats on both the control and supplemented diet (P = 0.034). Cats fed the supplemented diets had lower hepatic Se concentrations (P <0.001) and excreted more Se in urine (P <0.001) compared to dogs. Furthermore, cats fed the Na2SeO3 supplement had greater Se clearance rates than dogs (P <0.001). There was no effect of species on plasma GPx activity. We conclude that cats can tolerate higher dietary Se concentrations as they are more efficient at excreting excess Se in the urine and storing less Se in the liver
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