Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 424625
Title Cultivation of Sponges, Sponge Cells and Symbionts: Achievements and Future Prospects
Author(s) Schippers, K.J.; Sipkema, D.; Osinga, R.; Smidt, H.; Pomponi, S.A.; Martens, D.E.; Wijffels, R.H.
Source Advances in Marine Biology 62 (2012). - ISSN 0065-2881 - p. 273 - 337.
Department(s) Bioprocess Engineering
Microbiological Laboratory
Aquaculture and Fisheries
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) marine natural-products - fresh-water sponge - biologically-active metabolites - chondrosia-reniformis nardo - petrosia-ficiformis poiret - ex-situ cultivation - organic-carbon doc - in-vitro - aplysina-aerophoba - secondary metabolites
Abstract Marine sponges are a rich source of bioactive compounds with pharmaceutical potential. Since biological production is one option to supply materials for early drug development, the main challenge is to establish generic techniques for small-scale production of marine organisms. We analysed the state of the art for cultivation of whole sponges, sponge cells and sponge symbionts. To date, cultivation of whole sponges has been most successful in situ; however, optimal conditions are species specific. The establishment of sponge cell lines has been limited by the inability to obtain an axenic inoculum as well as the lack of knowledge on nutritional requirements in vitro. Approaches to overcome these bottlenecks, including transformation of sponge cells and using media based on yolk, are elaborated. Although a number of bioactive metabolite-producing microorganisms have been isolated from sponges, and it has been suggested that the source of most sponge-derived bioactive compounds is microbial symbionts, cultivation of sponge-specific microorganisms has had limited success. The current genomics revolution provides novel approaches to cultivate these microorganisms
There are no comments yet. You can post the first one!
Post a comment
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.