Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 424745
Title Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence target of a fungus and a nematode
Author(s) Lozano, J.; Wilbers, R.H.P.; Gawronski, P.; Boshoven, J.C.; Finkers-Tomczak, A.M.; Cordewener, J.H.G.; America, A.H.P.; Overmars, H.A.; Klooster, J.W. van t; Baranowski, L.; Sobczak, M.; Ilyas, M.; Hoorn, R.A.L. van der; Schots, A.; Wit, P.J.G.M. de; Bakker, J.; Goverse, A.; Smant, G.
Source Proceedings of the National Academy of Sciences of the United States of America 109 (2012)25. - ISSN 0027-8424 - p. 10119 - 10124.
DOI https://doi.org/10.1073/pnas.1202867109
Department(s) Laboratory of Nematology
Laboratory of Phytopathology
PRI BIOS Applied Genomics & Proteomics
EPS-2
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) potato cyst-nematodes - for-gene specificity - globodera-rostochiensis - phytophthora-infestans - physical interaction - confers resistance - plant-pathogens - protein - defense - effector
Abstract Plants lack the seemingly unlimited receptor diversity of a somatic adaptive immune system as found in vertebrates and rely on only a relatively small set of innate immune receptors to resist a myriad of pathogens. Here, we show that disease-resistant tomato plants use an efficient mechanism to leverage the limited nonself recognition capacity of their innate immune system. We found that the extracellular plant immune receptor protein Cf-2 of the red currant tomato (Solanum pimpinellifolium) has acquired dual resistance specificity by sensing perturbations in a common virulence target of two independently evolved effectors of a fungus and a nematode. The Cf-2 protein, originally identified as a monospecific immune receptor for the leaf mold fungus Cladosporium fulvum, also mediates disease resistance to the root parasitic nematode Globodera rostochiensis pathotype Ro1-Mierenbos. The Cf-2-mediated dual resistance is triggered by effector-induced perturbations of the apoplastic Rcr3(pim) protein of S. pimpinellifolium. Binding of the venom allergen-like effector protein Gr-VAP1 of G. rostochiensis to Rcr3(pim) perturbs the active site of this papain-like cysteine protease. In the absence of the Cf-2 receptor, Rcr3(pim) increases the susceptibility of tomato plants to G. rostochiensis, thus showing its role as a virulence target of these nematodes. Furthermore, both nematode infection and transient expression of Gr-VAP1 in tomato plants harboring Cf-2 and Rcr3(pim) trigger a defense-related programmed cell death in plant cells. Our data demonstrate that monitoring host proteins targeted by multiple pathogens broadens the spectrum of disease resistances mediated by single plant immune receptors.
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