Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 424950
Title How to build a pathogen detector: structural basis of NB-LRR function
Author(s) Takken, F.L.W.; Goverse, A.
Source Current Opinion in Plant Biology 15 (2012)4. - ISSN 1369-5266 - p. 375 - 384.
DOI http://dx.doi.org/10.1016/j.pbi.2012.05.001
Department(s) Laboratory of Nematology
EPS-2
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) disease resistance protein - tobacco-mosaic-virus - rich repeat protein - c-terminal domain - cell-death - coiled-coil - flax rust - effector recognition - crystal-structure - arabidopsis eds1
Abstract Many plant disease resistance (R) proteins belong to the family of nucleotide-binding-leucine rich repeat (NB-LRR) proteins. NB-LRRs mediate recognition of pathogen-derived effector molecules and subsequently activate host defence. Their multi-domain structure allows these pathogen detectors to simultaneously act as sensor, switch and response factor. Structure–function analyses and the recent elucidation of the 3D structures of subdomains have provided new insight in how these different functions are combined and what the contribution is of the individual subdomains. Besides interdomain contacts, interactions with chaperones, the proteasome and effector baits are required to keep NB-LRRs in a signalling-competent, yet auto-inhibited state. In this review we explore operational models of NB-LRR functioning based on recent advances in understanding their structure
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