Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 425345
Title Recombinant lactic acid bacteria as mucosal biotherapeutic agents
Author(s) Daniel, C.; Roussel, Y.; Kleerebezem, M.; Pot, B.
Source Trends in Biotechnology 29 (2011)10. - ISSN 0167-7799 - p. 499 - 508.
DOI http://dx.doi.org/10.1016/j.tibtech.2011.05.002
Department(s) Host Microbe Interactomics
Microbiological Laboratory
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) lactobacillus-plantarum genes - modified lactococcus-lactis - in-vivo - immunomodulatory properties - listeria-monocytogenes - protective antigen - immune-responses - epithelial-cells - vaccine delivery - lethal challenge
Abstract The safety status of lactic acid bacteria (LAB) and their capacity to survive the passage through the gastrointestinal tract (GI tract) have rendered them excellent candidates for the production of therapeutic proteins and their delivery in situ to the GI tract. During the past two decades, major health benefits of mucosally administered recombinant LAB have been successfully demonstrated, predominantly using animal models. However, the field has recently moved into the era of human clinical trials. In this review, we provide a timely update on the recent important advances made in this field, and outline the potential of recombinant LAB as therapeutic tools for their safe and efficient use in human health.
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