Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 425592
Title Amino acids incidence of hypertension in a Dutch older population: the Rotterdam study
Author(s) Neve, M. De; Kuil, W. van der; Engberink, M.F.; Rooij, F.J.A. van; Hofman, A.; Witteman, J.C.M.; Geleijnse, J.M.
Source Journal of Epidemiology and Community Health 65 (2011)S1. - ISSN 0143-005X - p. A222 - A222.
DOI http://dx.doi.org/10.1136/jech.2011.142976h.46
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
VLAG
Publication type Abstract in scientific journal or proceedings
Publication year 2011
Abstract Background Epidemiological studies have shown an association between dietary protein and hypertension, which may be attributed to specific amino acids (AAs). We examined the relation of dietary arginine, cysteine, lysine, proline and tyrosine with incident hypertension in 1958 men and women from the Rotterdam Study, aged =55 years, who were not treated with antihypertensive medication and were normotensive at baseline. Methods HRs (95% CI) were calculated in tertiles of AA intake (expressed as percentage of total protein intake), using a Cox proportional model with adjustment for age, gender, BMI, smoking, alcohol intake, education, and intake of energy and several nutrients. Results Mean systolic and diastolic blood pressure levels were 122±12 mm Hg and 69±9 mm Hg and dietary protein intake was 82±20 g/day (~17 en%). Arginine (with nuts being the main source) contributed 5.3±0.4% of total protein intake, cysteine contributed 1.4±0.1% (main source: grain), lysine 6.8±0.4% (main source: meat), proline 7.4±0.6% (main source: dairy and grain), and tyrosine 3.7±0.1% (main source: dairy). Intake of these AAs was not significantly associated with incident hypertension (HRs ranging from 0.84 to 1.15; ptrend =0.15). We observed, however, a tendency towards an increased risk for lysine (HR upper tertile vs lower tertile 1.15; ptrend=0.21) and towards a decreased risk for tyrosine (HR 0.86; ptrend=0.15). Conclusion We found no significant associations between AAs, and incidence of hypertension in this older population. There was, however, a tendency towards an adverse effect of lysine and a beneficial effect of tyrosine, which warrants further investigation in larger prospective studies.
Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.