Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 425753
Title Pedigree- and marker-based methods in the estimation of genetic diversity in small groups of Holstein cattle
Author(s) Engelsma, K.A.; Veerkamp, R.F.; Calus, M.P.L.; Bijma, P.; Windig, J.J.
Source Journal of Animal Breeding and Genetics 129 (2012)3. - ISSN 0931-2668 - p. 195 - 205.
Department(s) Animal Breeding and Genetics
LR - Backoffice
Livestock Research
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) effective population-size - genome-wide association - linkage disequilibrium - dairy-cattle - inbreeding coefficients - finnish ayrshire - fertility traits - selection - breeds - conservation
Abstract Genetic diversity is often evaluated using pedigree information. Currently, diversity can be evaluated in more detail over the genome based on large numbers of SNP markers. Pedigree- and SNP-based diversity were compared for two small related groups of Holstein animals genotyped with the 50 k SNP chip, genome-wide, per chromosome and for part of the genome examined. Diversity was estimated with coefficient of kinship (pedigree) and expected heterozygosity (SNP). SNP-based diversity at chromosome regions was determined using 5-Mb sliding windows, and significance of difference between groups was determined by bootstrapping. Both pedigree- and SNP-based diversity indicated more diversity in one of the groups; 26 of the 30 chromosomes showed significantly more diversity for the same group, as did 25.9% of the chromosome regions. Even in small populations that are genetically close, differences in diversity can be detected. Pedigree- and SNP-based diversity give comparable differences, but SNP-based diversity shows on which chromosome regions these differences are based. For maintaining diversity in a gene bank, SNP-based diversity gives a more detailed picture than pedigree-based diversity.
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