Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 425755
Title Genome-wide associations for fertility traits in Holstein–Friesian dairy cows using data from experimental research herds in four European countries
Author(s) Berry, D.P.; Bastiaansen, J.W.M.; Veerkamp, R.F.; Wijga, S.; Wall, E.; Berglund, B.; Calus, M.P.L.
Source Animal 6 (2012)8. - ISSN 1751-7311 - p. 1206 - 1215.
DOI http://dx.doi.org/10.1017/S1751731112000067
Department(s) Animal Breeding and Genetics
LR - Backoffice
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) linkage disequilibrium - luteal activity - milk-yield - cattle - selection - accuracy - information - haplotypes - endocrine - system
Abstract Genome-wide association studies for difficult-to-measure traits are generally limited by the sample population size with accurate phenotypic data. The objective of this study was to utilise data on primiparous Holstein–Friesian cows from experimental farms in Ireland, the United Kingdom, the Netherlands and Sweden to identify genomic regions associated with traditional measures of fertility, as well as a fertility phenotype derived from milk progesterone profiles. Traditional fertility measures investigated were days to first heat, days to first service, pregnancy rate to first service, number of services and calving interval (CI); post-partum interval to the commencement of luteal activity (CLA) was derived using routine milk progesterone assays. Phenotypic and genotypic data on 37 590 single nucleotide polymorphisms (SNPs) were available for up to 1570 primiparous cows. Genetic parameters were estimated using linear animal models, and univariate and bivariate genome-wide association analyses were undertaken using Bayesian stochastic search variable selection performed using Gibbs sampling. Heritability estimates of the traditional fertility traits varied from 0.03 to 0.16; the heritability for CLA was 0.13. The posterior quantitative trait locus (QTL) probabilities, across the genome, for the traditional fertility measures were all
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