Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 425907
Title Birth of new spliceosomal introns in fungi by multiplication of introner-like elements
Author(s) Burgt, A. van der; Severing, E.I.; Collemare, J.; Wit, P.J.G.M. de
Source Current Biology 22 (2012)13. - ISSN 0960-9822 - p. 1260 - 1265.
DOI https://doi.org/10.1016/j.cub.2012.05.011
Department(s) Laboratory of Phytopathology
Bioinformatics
EPS-2
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) evolution - gain - genomics
Abstract Spliceosomal introns are noncoding sequences that separate exons in eukaryotic genes and are removed from pre-messenger RNAs by the splicing machinery. Their origin has remained a mystery in biology since their discovery [ [1] and [2]] because intron gains seem to be infrequent in many eukaryotic lineages [ [3] and [4]]. Although a few recent intron gains have been reported [ [5] and [6]], none of the proposed gain mechanisms [7] can convincingly explain the high number of introns in present-day eukaryotic genomes. Here we report on particular spliceosomal introns that share high sequence similarity and are reminiscent of introner elements [8]. These elements multiplied in unrelated genes of six fungal genomes and account for the vast majority of intron gains in these fungal species. Such introner-like elements (ILEs) contain all typical characteristics of regular spliceosomal introns (RSIs) [ [9] and [10]] but are longer and predicted to harbor more stable secondary structures. However, dating of multiplication events showed that they degenerate in sequence and length within 100,000 years to eventually become indistinguishable from RSIs. We suggest that ILEs not only account for intron gains in six fungi but also in ancestral eukaryotes to give rise to most RSIs by a yet unknown multiplication mechanism
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