Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 426008
Title The Distribution of Mobile Genetic Elements (MGEs) in MRSA CC398 Is Associated with Both Host and Country
Author(s) McCarthy, A.J.; Witney, A.A.; Gould, K.A.; Moodley, A.; Guardabassi, L.; Voss, A.; Denis, O.; Broens, E.M.; Hinds, J.; Lindsay, J.A.
Source Genome Biology and Evolution 3 (2011). - ISSN 1759-6653 - p. 1164 - 1174.
DOI http://dx.doi.org/10.1093/gbe/evr092
Department(s) Quantitative Veterinary Epidemiology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) resistant staphylococcus-aureus - factor-binding-protein - methicillin-resistant - comparative genomics - st398 - pigs - infection - humans - specificity - adaptation
Abstract Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S. aureus microarray (SAM-62) to compare genomes of isolates from three geographical areas ( Belgium, Denmark, and Netherlands) to understand how CC398 colonizes different mammalian hosts. The core genomes of 44 pig isolates and 32 isolates from humans did not vary. However, mobile genetic element (MGE) distribution was variable including SCCmec. phi 3 bacteriophage and human specificity genes (chp, sak, scn) were found in invasive human but not pig isolates. SaP15 and putative ruminant specificity gene variants (vwb and scn) were common but not pig specific. Virulence and resistance gene carriage was host associated but country specific. We conclude MGE exchange is frequent in CC398 and greatest among populations in close contact. This feature may help determine epidemiological associations among isolates of the same lineage.
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