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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 426821
Title Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis
Author(s) Feskens, E.J.M.; Kromhout, D.
Source International Journal of Epidemiology 41 (2012)5. - ISSN 0300-5771 - p. 1419 - 1433.
DOI http://dx.doi.org/10.1093/ije/dys086
Department(s) Chair Nutrition and Disease
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) cause-specific mortality - coronary-heart-disease - childhood socioeconomic circumstances - body-mass index - cancer-risk - cardiovascular-disease - diabetes-mellitus - men - women - associations
Abstract Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5¿cm, using individual–participant data on 174¿374 deaths or major non-fatal vascular outcomes recorded among 1¿085¿949 people in 121 prospective studies. Results For people born between 1900 and 1960, mean adult height increased 0.5–1¿cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5¿cm greater height were 0.97 (95% confidence interval: 0.96–0.99) for death from any cause, 0.94 (0.93–0.96) for death from vascular causes, 1.04 (1.03–1.06) for death from cancer and 0.92 (0.90–0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5¿cm greater height ranged from 1.26 (1.12–1.42) for risk of melanoma death to 0.84 (0.80–0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases
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