Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 426888
Title TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis
Author(s) Lu, Y.; Boer, J.M.A.; Barsova, R.; Favorava, O.; Goel, A.; König, I.; Muller, M.R.; Feskens, E.J.M.
Source BMC Medical Genetics 13 (2012). - ISSN 1471-2350
DOI http://dx.doi.org/10.1186/1471-2350-13-39
Department(s) Microbiological Laboratory
Chair Nutrition Metabolism and Genomics
Chair Nutrition and Disease
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) growth-factor-beta - transforming growth-factor-beta-1 gene - abdominal aortic-aneurysm - human atherosclerotic lesions - genome-wide association - myocardial-infarction - artery-disease - compensatory enlargement - intracranial aneurysm - intravascular ultrasound
Abstract Background Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent. Methods We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported for the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed. Results Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95% confidence interval [CI]: 1.05-1.24), 1.18 (95% CI: 1.04-1.35), and 1.16 (95% CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk. Conclusion Two genetic variants (rs1800469 and rs1982073) in TGFbeta1 are associated with CHD risk, minor allele carriers having a 15% increased risk
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