Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 426953
Title Carbohydrates, glycemic index, glycemic load, and colorectal cancer risk : a systematic review and meta-analysis of cohort studies
Author(s) Aune, D.; Chan, D.S.M.; Lau, R.; Vieira, R.; Greenwood, D.C.; Kampman, E.; Norat, T.
Source Cancer Causes and Control 23 (2012)4. - ISSN 0957-5243 - p. 521 - 535.
DOI http://dx.doi.org/10.1007/s10552-012-9918-9
Department(s) Chair Nutrition and Disease
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) growth-factor-i - plasma c-peptide - dietary carbohydrate - womens health - adenomatous polyps - binding-proteins - insulin index - large-bowel - men - colon
Abstract Background Dietary carbohydrate, glycemic index, and glycemic load are thought to influence colorectal cancer risk through hyperinsulinemia. We review and quantitatively summarize in a meta-analysis the evidence from prospective cohort studies. Methods We searched the PubMed database for prospective studies of carbohydrate, glycemic index, and glycemic load and colorectal cancer risk, up to October 2011. Summary relative risks were estimated by the use of a random effects model. Results We identified 14 cohort studies that could be included in the meta-analysis of carbohydrate, glycemic index, and glycemic load and colorectal cancer risk. The summary RR for high versus low intake was 1.00 (95% CI: 0.87–1.14, I 2 = 31%) for carbohydrate, 1.07 (95% CI: 0.99–1.16, I 2 = 28%) for glycemic index, and 1.00 (95% CI: 0.91–1.10, I 2 = 39%) for glycemic load. In the dose–response analysis, the summary RR was 0.95 (95% CI: 0.84–1.07, I 2 = 58%) per 100 grams of carbohydrate per day, 1.07 (95% CI: 0.99–1.15, I 2 = 39%) per 10 glycemic index units, and 1.01 (95% CI: 0.95–1.08, I 2 = 47%) per 50 glycemic load units. Exclusion of one or two outlying studies reduced the heterogeneity, but the results were similar. Conclusion This meta-analysis of cohort studies does not support an independent association between diets high in carbohydrate, glycemic index, or glycemic load and colorectal cancer risk
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