Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 426965
Title Dairy products and colorectal cancer risk : a systematic review and meta-analysis of cohort studies
Author(s) Aune, D.; Lau, R.; Chan, D.S.M.; Vieira, R.; Greenwood, D.C.; Kampman, E.; Norat, T.
Source Annals of Oncology 23 (2012)1. - ISSN 0923-7534 - p. 37 - 45.
Department(s) Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) vitamin-d intake - epithelial-cell proliferation - food frequency questionnaire - japan collaborative cohort - dose-response data - colon-cancer - dietary calcium - womens health - milk consumption - united-states
Abstract Background: Previous studies of the association between intake of dairy products and colorectal cancer risk have indicated an inverse association with milk, however, the evidence for cheese or other dairy products is inconsistent. Methods: We conducted a systematic review and meta-analysis to clarify the shape of the dose–response relationship between dairy products and colorectal cancer risk. We searched the PubMed database for prospective studies published up to May 2010. Summary relative risks (RRs) were estimated using a random effects model. Results: Nineteen cohort studies were included. The summary RR was 0.83 (95% CI [confidence interval]: 0.78–0.88, I2 = 25%) per 400 g/day of total dairy products, 0.91 (95% CI: 0.85–0.94, I2 = 0%) per 200 g/day of milk intake and 0.96 (95% CI: 0.83–1.12, I2 = 28%) per 50 g/day of cheese. Inverse associations were observed in both men and women but were restricted to colon cancer. There was evidence of a nonlinear association between milk and total dairy products and colorectal cancer risk, P <0.001, and the inverse associations appeared to be the strongest at the higher range of intake. Conclusion: This meta-analysis shows that milk and total dairy products, but not cheese or other dairy products, are associated with a reduction in colorectal cancer risk
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