Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427264
Title Characterization of SOC1’s Central Role in Flowering by the Identification of Its Upstream and Downstream Regulators1[C][W]
Author(s) Immink, R.G.H.; Posé, D.; Ferrario, S.I.T.; Ott, F.; Kaufmann, K.; Valentim, F.L.; Folter, S. de; Wal, F. van der; Dijk, A.D.J. van; Schmid, M.; Angenent, G.C.
Source Plant Physiology 160 (2012)1. - ISSN 0032-0889 - p. 433 - 449.
Department(s) PRI BIOS Plant Development Systems
PRI Bioscience
Laboratory of Molecular Biology
Biometris (WU MAT)
PRI BIOS Applied Bioinformatics
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) floral organ identity - mads domain proteins - time gene soc1 - arabidopsis-thaliana - transcription factor - homeotic gene - target genes - negative regulator - ectopic expression - meristem identity
Abstract The transition from vegetative to reproductive development is one of the most important phase changes in the plant life cycle. This step is controlled by various environmental signals that are integrated at the molecular level by so-called floral integrators. One such floral integrator in Arabidopsis (Arabidopsis thaliana) is the MADS domain transcription factor SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1). Despite extensive genetic studies, little is known about the transcriptional control of SOC1, and we are just starting to explore the network of genes under the direct control of SOC1 transcription factor complexes. Here, we show that several MADS domain proteins, including SOC1 heterodimers, are able to bind SOC1 regulatory sequences. Genome-wide target gene analysis by ChIP-seq confirmed the binding of SOC1 to its own locus and shows that it also binds to a plethora of flowering-time regulatory and floral homeotic genes. In turn, the encoded floral homeotic MADS domain proteins appear to bind SOC1 regulatory sequences. Subsequent in planta analyses revealed SOC1 repression by several floral homeotic MADS domain proteins, and we show that, mechanistically, this depends on the presence of the SOC1 protein. Together, our data show that SOC1 constitutes a major hub in the regulatory networks underlying floral timing and flower development and that these networks are composed of many positive and negative autoregulatory and feedback loops. The latter seems to be crucial for the generation of a robust flower-inducing signal, followed shortly after by repression of the SOC1 floral integrator.
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