Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427290
Title Role of the intestinal microbiome in health and disease: from correlation to causation
Author(s) Vos, W.M. de; Vos, E.A.
Source Nutrition Reviews 70 (2012)suppl. 1. - ISSN 0029-6643 - p. S45 - S56.
Department(s) Microbiological Laboratory
FB Inkoop
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) inflammatory-bowel-disease - 16s ribosomal-rna - gastrointestinal-tract microbiota - gradient gel-electrophoresis - distal gut microbiota - fecal microbiota - celiac-disease - phylogenetic microarray - akkermansia-muciniphila - commensal microbiota
Abstract Recorded observations indicating an association between intestinal microbes and health are long-standing in terms of specific diseases, but emerging high-throughput technologies that characterize microbial communities in the intestinal tract are suggesting new roles for the supposedly normal microbiome. This review considers the nature of the evidence supporting a relationship between the microbiota and the predisposition to disease as associative, correlative, or causal. Altogether, indirect or associative support currently dominates the evidence base, which now suggests that the intestinal microbiome can be linked to a growing number of over 25 diseases or syndromes. While only a handful of cause-and-effect studies have been performed, this form of evidence is increasing. The results of such studies are expected to be useful in monitoring disease development, in providing a basis for personalized treatments, and in indicating future therapeutic avenues
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