Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427297
Title Early-life gut microbiota under physiological and pathological conditions : the central role of combined meta-omics-based approaches
Author(s) Chierico, F. Del; Vernocchi, P.; Bonizzi, L.; Vos, W.M. de
Source Journal of Proteomics 75 (2012)15. - ISSN 1874-3919 - p. 4580 - 4587.
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) inflammatory-bowel-disease - intestinal microbiota - systems biology - fecal microbiota - metabonomics - newborns - host - identification - pathogenesis - communities
Abstract The establishment of gut microbiota immediately after birth is modulated by different mechanisms that can be considered specific determinants of temporal and spatial variability. Over the last few years, molecular methods have been offering a complementary support to the classical microbiology, often underpowered by its inability to provide unbiased representation of gut microbiota. The advent of high-throughput-omics-based methods has opened new avenues in the knowledge of the gut ecosystem by shedding light on its shape and modulation. Such methods may unveil taxa distribution, role and density of microbial habitants, hence highlighting individual phenotyping (physiological traits) and their relationship with gut dysbiosis, inflammation processes, metabolic disorders (pathological conditions). Synergic meta-omics or "systems biology"-based approaches may concur in providing advanced information on microbiota establishment and pathogen control. During early-life stages this massive amount of data may provide gut microbiota descriptive and functional charts which can be exploited to perform a good practice in childcare and pediatrics, thus providing nutraceutical benefits and endorsing healthy development and aging. This article is part of a Special Issue entitled: Translational Proteomics
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