Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427320
Title Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age
Author(s) Cheng, J.; Palva, A.M.; Vos, W.M. de; Satokari, R.
Source Current Topics in Microbiology and Immunology 358 (2013). - ISSN 0070-217X - p. 323 - 346.
DOI http://dx.doi.org/10.1007/82_2011_189
Department(s) Laboratory of Plant Breeding
Microbiological Laboratory
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) irritable-bowel-syndrome - gradient gel-electrophoresis - randomized-controlled-trial - fatty liver-disease - 16s ribosomal-rna - fecal bifidobacterium populations - human gut microbiota - diet-induced obesity - real-time pcr - celiac-disease
Abstract Our intestinal tract is colonized since birth by multiple microbial species that show a characteristic succession in time. Notably the establishment of the microbiota in early life is important as it appears to impact later health. While apparently stable in healthy adults, the intestinal microbiota is changing significantly during aging. After 100 years of symbiosis marked changes have been observed that may relate to an increased level of intestinal inflammation. There is considerable interest in the microbiota in health and disease as it may provide functional biomarkers, the possibility to differentiate subjects, and avenues for interventions. This chapter reviews the present state of the art on the research to investigate the contribution of the intestinal microbiota to human health. Specific attention will be given to the healthy microbiota and aberrations due to disturbances such as celiac disease, irritable bowel syndrome, inflammatory bowel disease, obesity and diabetes, and non-alcoholic fatty liver disease
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