Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 427472
Title The Constructor: a web application optimizing cloning strategies based on modules from the registry of standard biological parts
Author(s) Hesselman, M.C.; Koehorst, J.J.; Slijkhuis, T.; Hugenholtz, F.; Odoni, D.I.; Passel, M.W.J. van
Source Journal of Biological Engineering 6 (2012). - ISSN 1754-1611 - 6 p.
DOI http://dx.doi.org/10.1186/1754-1611-6-14
Department(s) Microbiological Laboratory
Systems and Synthetic Biology
VLAG
WIMEK
Publication type Refereed Article in a scientific journal
Publication year 2012
Abstract Synthetic biology is an emerging field that combines molecular biology with engineering principles, which requires abstraction levels applied to a modular biological componentry. The Registry of Standard Biological Parts harbours such a repository of standardized parts, and thereby facilitates the combination of complex molecular modules to novel genetic circuits and devices. However, since finding the best parts for a pre-determined genetic design can be time consuming, we devised the Constructor, a web tool that recommends the smallest number of cloning steps for pre-designed circuits, and implements user-defined quality checks.We present the Constructor (www.systemsbiology.nl/the_constructor) as a constructive web tool that simplifies the in silico assembly of pre-designed gene circuitries from standard parts, reducing both planning and subsequent cloning time
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