Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427500
Title A mathematical model for BRI1 mediated signaling in root growth and hypocotyl elongation
Author(s) Esse, G.W. van; Mourik, S. van; Stigter, J.D.; Hove, C.C.A. ten; Molenaar, J.; Vries, S.C. de
Source Plant Physiology 160 (2012). - ISSN 0032-0889 - p. 523 - 532.
DOI https://doi.org/10.1104/pp.112.200105
Department(s) Biochemistry
Biometris (WU MAT)
EPS-1
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) receptor kinase bri1 - single-molecule analysis - arabidopsis-thaliana - plasma-membrane - gene-expression - plant-growth - negative cooperativity - biosynthesis inhibitor - structural basis - auxin transport
Abstract Brassinosteroid (BR) signaling is essential for plant growth and development. In Arabidopsis (Arabidopsis thaliana), BRs are perceived by the BRASSINOSTEROID INSENSITIVE1 (BRI1) receptor. Root growth and hypocotyl elongation are convenient downstream physiological outputs of BR signaling. A computational approach was employed to predict root growth solely on the basis of BRI1 receptor activity. The developed mathematical model predicts that during normal root growth, few receptors are occupied with ligand. The model faithfully predicts root growth, as observed in bri1 loss-of-function mutants. For roots, it incorporates one stimulatory and two inhibitory modules, while for hypocotyls, a single inhibitory module is sufficient. Root growth as observed when BRI1 is overexpressed can only be predicted assuming that a decrease occurred in the BRI1 half-maximum response values. Root growth appears highly sensitive to variation in BR concentration and much less to reduction in BRI1 receptor level, suggesting that regulation occurs primarily by ligand availability and biochemical activity.
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