Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427533
Title Molecular cloning and expression of two B-defensin and two mucin genes in common carp (Cyprinus carpio L.) and their up-regulation after B-glucan feeding
Author(s) Marel, M.C. van der; Adamek, M.; Gonzalez, S.F.; Frost, P.; Rombout, J.H.W.M.; Wiegertjes, G.F.; Savelkoul, H.F.J.; Steinhagen, D.
Source Fish and Shellfish Immunology 32 (2012)3. - ISSN 1050-4648 - p. 494 - 501.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) gram-negative bacteria - salmo-salar l - disease resistance - immune-responses - atlantic salmon - secreted mucins - infection - fish - macrophages - microbiota
Abstract In this study, we described the partial structure, mRNA tissue distribution and regulation of two carp mucin and two ß-defensin genes. This is the first description of these genes in fish. The genes might provide relevant tools to monitor feed-related improvements of fish health under aquaculture conditions. Carp mucin 2 and mucin 5B genes show a high similarity to their mammalian and avian counterparts. The carp ß-defensin 1 and ß-defensin 2 genes cluster together well with their piscine family members. The influence of a ß-glucan immunomodulant on the expression of these genes in mucosal tissues could be confirmed for the first time. Muc5B expression was significantly increased in the skin. For Muc2 no significant up- or down-regulation could be observed. Significantly higher expression levels of ß-defensin 2 in gills and both ß-defensin genes in skin were found. Thus, the mucosal system can be influenced by the addition of ß-glucans to the food
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