Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427575
Title Recent developments in basophil research : do basophils initiate and perpetuate type 2 T-helper cell responses?
Author(s) Beek, A.A. van; Knol, E.F.; Vos, P. de; Smelt, M.J.; Savelkoul, H.F.J.; Neerven, R.J.J. van
Source International Archives of Allergy and Immunology 160 (2013)1. - ISSN 1018-2438 - p. 7 - 17.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) thymic stromal lymphopoietin - antigen-presenting cells - chronic allergic inflammation - human blood basophils - in-vivo - cytokine production - dendritic cells - mast-cells - helminth infection - histamine-release
Abstract Basophils account for only 0.1–1% of all peripheral blood leukocytes. They were considered to be a redundant cell type for a long time. However, several findings show a non-redundant role for basophils in type 2 T-helper cell (Th2) immune responses in helminth infections, allergy and autoimmunity. Both immunoglobulin-E-dependent and -independent pathways have been described to contribute to basophil activation. In addition, several recent studies reported that basophils can function as antigen-presenting cells and are important in the initiation of Th2 immune responses. However, there are also conflicting studies that do not corroborate the importance of basophils in Th2 immune responses. This review discusses the role of basophils in Th2 immune responses in view of these recent findings
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