Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427814
Title Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European prospective investigation into cancer and nutrition
Author(s) Jeurnink, S.M.; Büchner, F.L.; Bueno-de Mesquita, H.B.; Siersema, P.D.; Boshuizen, H.C.; Numans, M.E.; Dahm, C.C.; Overvad, K.; Tjonneland, A.; Roswall, N.; Clavel-Chapelon, F.; Boutron-Ruault, M.C.; Morois, S.; Kaaks, R.; Teucher, B.; Boeing, H.; Buijsse, B.; Trichopoulou, A.; Benetou, V.; Zylis, D.; Palli, D.; Sieri, S.; Vineis, P.; Tumino, R.; Panico, S.; Ocké, M.C.; Peeters, P.H.; Skeie, G.; Brustad, M.; Lund, E.; Sanchez-Cantalejo, E.; Navarro, C.; Amiano, P.; Ardanaz, E.; Ramón Quirós, J.; Hallmans, G.; Johansson, I.; Lindkvist, B.; Regnér, S.; Khaw, K.T.; Wareham, N.; Key, T.J.; Slimani, N.; Norat, T.; Vergnaud, A.C.; Romaguera, D.; Gonzalez, C.A.
Source International Journal of Cancer 131 (2012)6. - ISSN 0020-7136 - p. E963 - E973.
Department(s) Biometris (WU MAT)
Chair Nutrition and Disease
Chair Nutrition and Health over the Lifecourse
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) epic-eurgast - epidemiologic evidence - helicobacter-pylori - physical-activity - diet diversity - cereal fiber - vitamin-c - stomach - adenocarcinomas - metaanalysis
Abstract Diets high in vegetables and fruits have been suggested to be inversely associated with risk of gastric cancer. However, the evidence of the effect of variety of consumption is limited. We therefore investigated whether consumption of a variety of vegetables and fruit is associated with gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition study. Data on food consumption and follow-up on cancer incidence were available for 452,269 participants from 10 European countries. After a mean follow-up of 8.4 years, 475 cases of gastric and esophageal adenocarcinomas (180 noncardia, 185 cardia, gastric esophageal junction and esophagus, 110 not specified) and 98 esophageal squamous cell carcinomas were observed. Diet Diversity Scores were used to quantify the variety in vegetable and fruit consumption. We used multivariable Cox proportional hazard models to calculate risk ratios. Independent from quantity of consumption, variety in the consumption of vegetables and fruit combined and of fruit consumption alone were statistically significantly inversely associated with the risk of esophageal squamous cell carcinoma (continuous hazard ratio per 2 products increment 0.88; 95% CI 0.79–0.97 and 0.76; 95% CI 0.62–0.94, respectively) with the latter particularly seen in ever smokers. Variety in vegetable and/or fruit consumption was not associated with risk of gastric and esophageal adenocarcinomas. Independent from quantity of consumption, more variety in vegetable and fruit consumption combined and in fruit consumption alone may decrease the risk of esophageal squamous cell carcinoma. However, residual confounding by lifestyle factors cannot be excluded
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