Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 427907
Title Microcapsules with a pH responsive polymer: Influence of the encapsulated oil on the capsule morphology
Author(s) Wagdare, N.A.; Marcelis, A.T.M.; Boom, R.M.; Rijn, C.J.M. van
Source Colloids and Surfaces. B: Biointerfaces 88 (2011)1. - ISSN 0927-7765 - p. 175 - 180.
DOI https://doi.org/10.1016/j.colsurfb.2011.06.028
Department(s) Laboratory for Organic Chemistry
Food Process Engineering
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) hollow polylactide microcapsules - premix membrane emulsification - internal phase-separation - mechanical-properties - shell microcapsules - emulsion droplets - lipophilic drugs - contrast agents - release - delivery
Abstract Microcapsules were prepared by microsieve membrane cross flow emulsification of Eudragit FS 30D/dichloromethane/edible oil mixtures in water, and subsequent phase separation induced by extraction of the dichloromethane through an aqueous phase. For long-chain triglycerides and jojoba oil, core–shell particles were obtained with the oil as core, surrounded by a shell of Eudragit. Medium chain triglyceride (MCT oil) was encapsulated as relatively small droplets in the Eudragit matrix. The morphology of the formed capsules was investigated with optical and SEM microscopy. Extraction of the oil from the core–shell capsules with hexane resulted in hollow Eudragit capsules with porous shells. It was shown that the differences are related to the compatibility of the oils with the shell-forming Eudragit. An oil with poor compatibility yields microcapsules with a dense Eudragit shell on a single oil droplet as the core; oils having better compatibility yield porous Eudragit spheres with several oil droplets trapped inside
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