Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 428077
Title A Gain-of-Function Polymorphism Controlling Complex Traits and Fitness in Nature
Author(s) Prasad, K.V.S.K.; Song, B.; Olson-Manning, C.; Anderson, J.T.; Lee, C.; Schranz, M.E.; Windsor, A.J.; Clauss, M.J.; Manzaneda, A.J.; Naqvi, I.; Reichelt, M.; Gershenzon, J.; Rupasinghe, S.G.; Schuler, M.A.; Mitchell-Olds, T.
Source Science 337 (2012)6098. - ISSN 0036-8075 - p. 1081 - 1084.
Department(s) Biosystematics
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) ecological genomics - boechera-stricta - arabidopsis - biosynthesis - cytochrome-p450 - cyp79f1 - cyp83b1 - plants
Abstract Identification of the causal genes that control complex trait variation remains challenging, limiting our appreciation of the evolutionary processes that influence polymorphisms in nature. We cloned a quantitative trait locus that controls plant defensive chemistry, damage by insect herbivores, survival, and reproduction in the natural environments where this polymorphism evolved. These ecological effects are driven by duplications in the BCMA (branched-chain methionine allocation) loci controlling this variation and by two selectively favored amino acid changes in the glucosinolate-biosynthetic cytochrome P450 proteins that they encode. These changes cause a gain of novel enzyme function, modulated by allelic differences in catalytic rate and gene copy number. Ecological interactions in diverse environments likely contribute to the widespread polymorphism of this biochemical function
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