Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 428500
Title Mucosal Vaccination and Therapy with Genetically Modified Lactic Acid Bacteria
Author(s) Wells, J.
Source In: Annual Review of Food Science and Technology : volume 2 / Doyle, M.P., Klaenhammer, T.R., - p. 423 - 445.
Department(s) Host Microbe Interactomics
Publication type Peer reviewed book chapter
Publication year 2011
Keyword(s) recombinant lactococcus-lactis - toxin fragment-c - human gastrointestinal-tract - mammalian epithelial-cells - bovine beta-lactoglobulin - surface protein-a - immune-responses - oral immunization - dendritic cells - tetanus toxin
Abstract Lactic acid bacteria (LAB) have proved to be effective mucosal delivery vehicles that overcome the problem of delivering functional proteins to the mucosal tissues. By the intranasal route, both live and killed LAB vaccine strains have been shown to elicit mucosal and systemic immune responses that afford protection against infectious challenges. To be effective via oral administration, frequent dosing over several weeks is required but new targeting and adjuvant strategies have clearly demonstrated the potential to increase the immunogenicity and protective immunity of LAB vaccines. Oral administration of Lactococcus lactis has been shown to induce antigen-specific oral tolerance (OT) to secreted recombinant antigens. LAB delivery is more efficient at inducing OT than the purified antigen, thus avoiding the need for purification of large quantities of antigen. This approach holds promise for new therapeutic interventions in allergies and antigen-induced autoimmune diseases. Several clinical and research reports demonstrate considerable progress in the application of genetically modified L. lactis for the treatment of inflammatory bowel disease (MD). New medical targets are on the horizon, and the approval by several health authorities and biosafety committees of a containment system for a genetically modified L. lactis that secretes Il-10 should pave the way for new LAB delivery applications in the future.
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