Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 428683
Title Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O-2(-):H2O2 Ratio and Confers Anoikis Resistance to Tumors
Author(s) Zhu, P.C.; Tan, M.J.; Huang, R.L.; Tan, C.K.; Chong, H.C.; Pal, M.; Lam, C.R.I.; Boukamp, P.; Pan, J.Y.; Tan, S.H.; Kersten, A.H.; Li, H.Y.; Ding, J.L.; Tan, N.S.
Source Cancer Cell 19 (2011)3. - ISSN 1535-6108 - p. 401 - 415.
DOI http://dx.doi.org/10.1016/j.ccr.2011.01.018
Department(s) Chair Nutrition Metabolism and Genomics
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) prostate-cancer cells - beta-carotene - cardiovascular-disease - hydrogen-peroxide - redox regulation - nadph oxidase - superoxide - metastasis - survival - expression
Abstract Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O-2(-). A high ratio of O-2(-):H2O2 oxidizes/activates Src, triggering the PI3K/PKB alpha and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O-2(-) production and a reduced O-2(-):H2O2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target.
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