Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 428776
Title Kinetics of the avian influenza-specific humoral responses in lung are indicative of local antibody production
Author(s) Geus, de, E.D.; Rebel, J.M.J.; Vervelde, L.
Source Developmental and Comparative Immunology 36 (2012)2. - ISSN 0145-305X - p. 317 - 322.
Department(s) CVI Infection Biology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) newcastle-disease virus - memory b-cells - lymphoid-tissue - chickens - infection - immunity - turkeys - serum - hemagglutinin - vaccination
Abstract The role and kinetics of respiratory immunoglobulins in AIV infection has not been investigated. In this study we determined the numbers of both total antibody secreting cells (ASC) and virus-specific ASC in lung, spleen, blood and bone marrow (BM) following low-pathogenic AIV infection. Antiviral humoral immune responses were induced both locally in the lung and systemically in the spleen. Responses in the lung and BM preceded responses in the spleen and in blood, with virus-specific IgY ASC already detected in lung and BM from 1 week post-primary inoculation, indicating that respiratory immune responses are not induced in the spleen, but locally in the lung. ASC present in the blood of the lungs and co-isolated during lymphocyte isolation from the lungs have no major impact on the ASC detected in the lungs based on statistical correlation
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