Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 428777
Title Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines
Author(s) Geus, de, E.D.; Rebel, J.M.J.; Vervelde, L.
Source Veterinary Quarterly 32 (2012)2. - ISSN 0165-2176 - p. 75 - 86.
Department(s) CVI Infection Biology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) infectious-bronchitis virus - newcastle-disease vaccine - cell-mediated-immunity - controls phagosomal ph - memory b-cells - dendritic cells - lymphoid-tissue - harderian-gland - plasma-cells - mycoplasma-gallisepticum
Abstract The risk and the size of an outbreak of avian influenza virus (AIV) could be restricted by vaccination of poultry. A vaccine used for rapid intervention during an AIV outbreak should be safe, highly effective after a single administration and suitable for mass application. In the case of AIV, aerosol vaccination using live virus is not desirable because of its zoonotic potential and because of the risk for virus reassortment. The rational design of novel mucosal-inactivated vaccines against AIV requires a comprehensive knowledge of the structure and function of the lung-associated immune system in birds in order to target vaccines appropriately and to design efficient mucosal adjuvants. This review addresses our current understanding of the induction of respiratory immune responses in the chicken. Furthermore, possible mucosal vaccination strategies for AIV are highlighted.
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