Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 428815
Title Regulation of tomato fruit pericarp development by an interplay between CDKB and CDKA1 cell cycle genes
Author(s) Czerednik, A.; Busscher, M.; Bielen, A.A.M.; Wolters-Arts, M.; Maagd, R.A. de; Angenent, G.C.
Source Journal of Experimental Botany 63 (2012)7. - ISSN 0022-0957 - p. 2605 - 2617.
Department(s) PRI BIOS Plant Development Systems
Laboratory for Organic Chemistry
Laboratory of Molecular Biology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) lycopersicon-esculentum mill - dependent kinase - endoreduplicating cells - arabidopsis - protein - plants - expression - division - growth - rich
Abstract Growth of tomato fruits is determined by cell division and cell expansion, which are tightly controlled by factors that drive the core cell cycle. The cyclin-dependent kinases (CDKs) and their interacting partners, the cyclins, play a key role in the progression of the cell cycle. In this study the role of CDKA1, CDKB1, and CDKB2 in fruit development was characterized by fruit-specific overexpression and down-regulation. CDKA1 is expressed in the pericarp throughout development, but is strongly up-regulated in the outer pericarp cell layers at the end of the growth period, when CDKB gene expression has ceased. Overexpression of the CDKB genes at later stages of development and the down-regulation of CDKA1 result in a very similar fruit phenotype, showing a reduction in the number of cell layers in the pericarp and alterations in the desiccation of the fruits. Expression studies revealed that CDKA1 is down-regulated by the expression of CDKB1/2 in CDKB1 and CDKB2 overexpression mutants, suggesting opposite roles for these types of CDK proteins in tomato pericarp development.
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