Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 429083
Title Iron metabolism is associated with adipocyte insulin resistance and plasma adiponectin
Author(s) Wlazlo, N.; Greevenbroek, M.M.J. van; Ferreira, I.; Jansen, E.H.J.M.; Feskens, E.J.M.; Kallen, C.J.H. van der; Schalkwijk, C.G.; Bravenboer, B.; Stehouwer, C.D.A.
Source Diabetes Care 36 (2013)2. - ISSN 0149-5992 - p. 309 - 315.
Department(s) Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) transferrin-bound iron - beta-cell function - serum ferritin - adipose-tissue - hereditary hemochromatosis - general-population - syndrome desir - fatty liver - risk - glucose
Abstract OBJECTIVE-Adipocyte insulin resistance (IR) is a key feature early in the pathogenesis of type 2 diabetes mellitus (T2DM), and although scarce, data in the literature suggest a direct role for iron and iron metabolism-related factors in adipose tissue function and metabolism. Serum ferritin and transferrin were shown to be associated with muscle insulin resistance (IR) and T2DM, but little is known about the role of iron metabolism on adipose tissue. We therefore investigated whether markers of iron metabolism were associated with adipocyte IR and plasma adiponectin. RESEARCH DESIGN AND METHODS-Serum ferritin, transferrin, total iron, non-transferrin-bound iron (NTBI), transferrin saturation, and plasma adiponectin were determined in 492 individuals. Adipocyte IR was defined by the product of fasting insulin and nonesterified fatty acids (NEFAs). Using linear regression analyses, we investigated the difference in adipocyte IR or adiponectin (in %) according to differences in iron metabolism markers. RESULTS-Serum ferritin (beta = 1.00% increase in adipocyte IR per 10 mu g/L [95% CI 0.66-1.34]), transferrin (4.18% per 0.1 g/L [2.88-5.50]), total iron (1.36% per mu mol/L [0.61-2.12]), and NTBI (5.14% per mu mol/L [1.88-8.52]) were associated with adipocyte IR after adjustment for several covariates, including inflammatory markers. All markers of iron metabolism were also associated with NEFAs (all P, 0.01). In addition, ferritin and transferrin were inversely associated with adiponectin (both P, 0.01). CONCLUSIONS-The observed associations of several markers of iron metabolism with adipocyte IR and adiponectin suggest that factors related to iron and iron metabolism may contribute to adipocyte IR early in the pathogenesis of T2DM. Diabetes Care 36:309-315, 2013
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