Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 429487
Title Protein Tyrosine Phosphatase-Induced Hyperactivity Is a Conserved Strategy of a Subset of BaculoViruses to Manipulate Lepidopteran Host Behavior
Author(s) Houte, S. van; Ros, V.I.D.; Mastenbroek, T.G.; Vendrig, N.J.; Hoover, K.; Spitzen, J.; Oers, M.M. van
Source PLoS One 7 (2012)10. - ISSN 1932-6203 - 11 p.
DOI http://dx.doi.org/10.1371/journal.pone.0046933
Department(s) Laboratory of Virology
Biometris (WU MAT)
Laboratory of Entomology
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) nuclear polyhedrosis-virus - spodoptera-exigua larvae - rna 5'-triphosphatase - feeding-behavior - aedes-aegypti - gene - impact - transmission - infection - silkworm
Abstract Many parasites manipulate host behavior to increase the probability of transmission. To date, direct evidence for parasitic genes underlying such behavioral manipulations is scarce. Here we show that the baculovirus Autographa californica nuclear polyhedrovirus (AcMNPV) induces hyperactive behavior in Spodoptera exigua larvae at three days after infection. Furthermore, we identify the viral protein tyrosine phosphatase (ptp) gene as a key player in the induction of hyperactivity in larvae, and show that mutating the catalytic site of the encoded phosphatase enzyme prevents this induced behavior. Phylogenetic inference points at a lepidopteran origin of the ptp gene and shows that this gene is well-conserved in a group of related baculoviruses. Our study suggests that ptp-induced behavioral manipulation is an evolutionarily conserved strategy of this group of baculoviruses to enhance virus transmission, and represents an example of the extended phenotype concept. Overall, these data provide a firm base for a deeper understanding of the mechanisms behind baculovirus-induced insect behavior.
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