Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 429503
Title Triazole fungicides and the selection of resistance to medical triazoles in the opportunistic mould Aspergillus fumigatus
Author(s) Verweij, P.E.; Kema, G.H.J.; Zwaan, B.J.; Melchers, W.J.G.
Source Pest Management Science 69 (2013)2. - ISSN 1526-498X - p. 165 - 170.
Department(s) PRI BIOINT Moleculair Phytopathology
Laboratory of Genetics
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) azole resistance - invasive aspergillosis - fungal disease - cyp51a gene - itraconazole - posaconazole - fluconazole - patient - surveillance - voriconazole
Abstract Azole resistance is an emerging problem in the opportunistic mould Aspergillus fumigatus. The triazoles are the most important agents for the management of Aspergillus diseases in humans. Selection for acquired resistance may occur in the hospital setting through exposure to high doses of azoles during azole therapy, but evidence is accumulating that A. fumigatus may become resistant to medical triazoles through environmental exposure to fungicides. The recovery of A. fumigatus isolates resistant to the medical triazoles from azole-naive patients as well as from the environment strongly indicates an environmental route of resistance selection. Molecule alignment studies have identified five fungicides that share a very similar molecule structure with the medical triazoles, and thus may have selected for mechanisms that confer resistance to both groups of compounds. It is important to explore further the presumed fungicide-driven route of resistance selection in order to implement effective preventive measures as the prevalence of azole resistance in A. fumigatus continues to increase and causes major challenges in the management of azole-resistant Aspergillus diseases
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