Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 429669
Title Short communication: A new bovine milk-protein variant: a-lactalbumin variant D.
Author(s) Visker, M.H.P.W.; Heck, J.M.; Valenberg, H.J.F. van; Arendonk, J.A.M. van; Bovenhuis, H.
Source Journal of Dairy Science 95 (2012)4. - ISSN 0022-0302 - p. 2165 - 2169.
DOI http://dx.doi.org/10.3168/jds.2011-4794
Department(s) Animal Breeding and Genetics
Product Design and Quality Management Group
VLAG
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) single-base polymorphisms - lactose synthetase - production traits - region - gene - cows - sequence - synthase - cattle
Abstract Capillary zone electrophoresis of 1,948 Holstein-Friesian cows suggested the presence of an unknown protein variant of α-lactalbumin (α-LA) in the milk of 1 cow. Sequencing genomic DNA of this cow showed a polymorphism in the α-LA gene (LAA) that appears to be responsible for this protein variant. This single nucleotide polymorphism g.600G > T was located in exon 2 of LAA and causes the amino acid change 65Gln > His in the α-LA protein. This α-LA protein variant is a new protein variant and should be called α-LA protein variant D. This amino acid change is not expected to affect protein function. Genomic DNA of 156 bulls of various dairy cattle breeds was screened to examine the presence of the new α-LA protein variant D. Single nucleotide polymorphism g.600G > T, responsible for α-LA protein variant D, was not found in any of the 156 bulls. However, 10 other polymorphisms in the coding and promoter regions of LAA were detected that were used to construct haplotypes.
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