Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 430748
Title Gut Microbial Metabolism of Polyphenols from Black Tea and Red Wine/Grape Juice Is Source-Specific and Colon-Region Dependent
Author(s) Dorsten, F.A. van; Peters, S.; Gross, G.; Gomez-Roldan, V.; Klinkenberg, M.; Vos, Ric de; Vaughan, E.E.; Duynhoven, J.P.M. van; Possemiers, S.; Wiele, T. van der; Jacobs, D.M.
Source Journal of Agricultural and Food Chemistry 60 (2012)45. - ISSN 0021-8561 - p. 11331 - 11342.
DOI http://dx.doi.org/10.1021/jf303165w
Department(s) PRI BIOS Applied Metabolic Systems
Microbiological Laboratory
Biophysics
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) chain fatty-acids - dietary polyphenols - phenolic-acids - intestinal microbiota - fermentation products - fecal microflora - food sources - flavonoids - degradation - identification
Abstract The colonic microbial degradation of a polyphenol-rich black tea extract (BTE) and red wine/grape juice extract (RWGE) was compared in a five-stage in vitro gastrointestinal model (TWINSHIME). Microbial metabolism of BTE and RWGE polyphenols in the TWINSHIME was studied subsequently in single- and continuous-dose experiments. A combination of liquid or gas chromatography with mass spectrometry (LC-MS or GC-MS) and NMR-based metabolic profiling was used to measure selected parent polyphenols, their microbial degradation into phenolic acids, and the production of short-chain fatty acids (SCFAs) in different colon compartments. Acetate production was increased by continuous feeding of BTE but not RWGE. During RWGE feeding, gallic acid and 4-hydroxyphenylpropionic acid remained elevated throughout the colon, while during BTE feeding, they were consumed in the distal colon, while 3-phenylpropionic acid was strongly produced. Gut microbial production of phenolics and SCFAs is dependent on colon location and polyphenol source, which may influence potential health benefits.
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