Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 430749
Title Nutrikinetics: concept, technololgies applications and perspectives
Author(s) Duynhoven, J.P.M. van; Velzen, E.J.J. van; Westerhuis, J.A.; Foltz, M.; Jacobs, D.M.; Smilde, A.K.
Source Trends in Food Science and Technology 26 (2012)1. - ISSN 0924-2244 - p. 4 - 13.
Department(s) Biophysics
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) human metabolic phenotypes - nutrition research - systems biology - intestinal microbiota - phenolic-acids - dietary phytochemicals - tea polyphenols - food components - gut microbiome - black tea
Abstract Exposure studies are the first step in predicting bioactivity of phytochemicals in humans. Due to the interaction between phytochemicals, their food matrix, the gut microbiome and the host, the resulting exogenous metabolites in systemic circulation vary largely between individuals. Nutrikinetics is an extension of the classical pharmacokinetic concept with explicit model adaptations. The concept relies on integrated deployment of metabolic profiling, multi-level data analysis and population-based single compartment modelling. Nutrikinetics is expected to make critical contributions in understanding how phenotypes and the food matrix modulate bioactivity of dietary phytochemicals, in particular when gut microbial bioconversions are involved.
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