Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 430931
Title Mimicking spray drying by drying of single droplets deposited on a flat surface
Author(s) Perdana, J.A.; Fox, M.B.; Schutyser, M.A.I.; Boom, R.M.
Source Food Bioprocess Technology 6 (2013)4. - ISSN 1935-5130 - p. 964 - 977.
DOI http://dx.doi.org/10.1007/s11947-011-0767-4
Department(s) Food Process Engineering
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) particle formation - kinetics - evaporation - inactivation - heat - simulation - levitator - models - layer - slabs
Abstract The inactivation of bioactive ingredients during spray drying is often matrix specific. Therefore, the design of new processes or the optimisation of existing spray drying processes is usually highly product specific and requires numerous experiments. Rapid experimentation methods that facilitate fast data generation are therefore desired. A novel method for drying single droplets to mimic spray drying is proposed. The approach involves droplet deposition on a hydrophobic flat surface followed by controlled drying. A heat and mass transfer model is applied to predict the drying history of the single droplets. The approach is successfully evaluated through studying the inactivation of ß-galactosidase during drying. The heat and mass transfer model supplemented with inactivation kinetics provided reasonable prediction of the residual enzyme activity after drying. In addition, the inactivation kinetics could be directly extracted from single droplet experiments rather than using the kinetics from separate heating experiments. Finally, it was demonstrated that the inactivation kinetics found with the single-drop experiments could satisfactorily predict the residual activity of ß-galactosidase dried with a laboratory-scale spray dryer.
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