Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 431165
Title Proteomic footprints of a member of Glossinavirus (Hytrosaviridae): An expeditious approach to virus control strategies in tsetse factories
Author(s) Kariithi, H.M.; Lent, J.W.M. van; Oers, M.M. van; Abd-Alla, A.M.M.; Vlak, J.M.
Source Journal of Invertebrate Pathology 112 (2013)suppl. 1. - ISSN 0022-2011 - p. S26 - S31.
Department(s) Laboratory of Virology
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) salivary-gland hypertrophy - mass-spectrometry - dna virus - morsitans-centralis - pallidipes diptera - musca-domestica - mature virion - female tsetse - protein - glossinidae
Abstract The Glossinavirus (Glossina pallidipes salivary gland hypertrophy virus (GpSGHV)) is a rod-shaped enveloped insect virus containing a 190,032bp-long, circular dsDNA genome. The virus is pathogenic for the tsetse fly Glossina pallidipes and has been associated with the collapse of selected mass-reared colonies. Maintenance of productive fly colonies is critical to tsetse and trypanosomiasis eradication in sub-Saharan Africa using the Sterile Insect Technique. Proteomics, an approach to define the expressed protein complement of a genome, was used to further our understanding of the protein composition, morphology, morphogenesis and pathology of GpSGHV. Additionally, this approach provides potential targets for novel and sustainable molecular-based antiviral strategies to control viral infections in tsetse colonies. To achieve this goal, identification of key protein partners involved in virus transmission is required. In this review, we integrate the available data on GpSGHV proteomics to assess the impact of viral infections on host metabolism and to understand the contributions of such perturbations to viral pathogenesis. The relevance of the proteome findings to tsetse and trypanosomiasis management in sub-Sahara Africa is also considered.
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