Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 431292
Title Chicken dendritic cells are susceptible to highly pathogenic avian influenza viruses which induce strong cytokine responses
Author(s) Vervelde, L.; Reemens, S.S.; Haarlem, D.A. van; Post, J.; Claassen, E.A.W.; Rebel, J.M.J.; Jansen, C.A.
Source Developmental and Comparative Immunology 39 (2013)3. - ISSN 0145-305X - p. 198 - 206.
DOI http://dx.doi.org/10.1016/j.dci.2012.10.011
Department(s) CVI Infection Biology
CVI Diagnostics and Crisis
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) ns1 protein - a virus - swine influenza - gene-expression - infection - interferon - activation - pathobiology - recognition - inhibition
Abstract Infection with highly pathogenic avian influenza (HPAI) in birds and mammals is associated with severe pathology and increased mortality. We hypothesize that in contrast to low pathogenicity avian influenza (LPAI) infection, HPAI infection of chicken dendritic cells (DC) induces a cytokine deregulation which may contribute to their highly pathogenic nature. Infection of DC with LPAI H7N1 and H5N2 resulted in viral RNA and NP expression without increase in time, in contrast to HPAI H7N1 and H5N2 mRNA expression. No increase in IFN mRNA was detected after infection with LPAI, but after LPAI H5N2, and not LPAI H7N1, infection the level of bioactive IFNa/ß significantly increased. After HPAI H7N1 and H5N2 infection, significant increases in IL-8, IFN-a, IFN-¿ mRNA expression and in TLR1, 3, and 21 mRNA were observed. This enhanced activation of DC after HPAI infection may trigger deregulation of the immune response as seen during HPAI infection in chickens.
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