Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 431399
Title Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes
Author(s) Georgieva, J.V.; Brinkhuis, R.P.; Stojanov, K.; Weijers, C.A.G.M.; Zuilhof, H.; Rutjes, F.P.J.T.; Hoekstra, D.; Hest, J.C.M. van; Zuhorn, I.S.
Source Angewandte Chemie-International Edition 51 (2012)33. - ISSN 1433-7851 - p. 8339 - 8342.
DOI https://doi.org/10.1002/anie.201202001
Department(s) Laboratory for Organic Chemistry
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) in-vivo - biodegradable polymersomes - nervous-system - delivery - nanoparticles - therapeutics - vesicles - protein - mouse
Abstract A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.
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