Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 431723
Title Vitamin B12 intake and status and cognitive function in elderly people
Author(s) Doets, E.L.; Wijngaarden, J.P. van; Szczecinska, A.; Dullemeijer, C.; Souverein, O.W.; Dhonukshe-Rutten, R.A.M.; Cavelaars, A.J.E.M.; Veer, P. van 't; Brzozowska, A.M.; Groot, C.P.G.M. de
Source Epidemiologic Reviews 35 (2013)1. - ISSN 0193-936X - p. 2 - 21.
DOI http://dx.doi.org/10.1093/epirev/mxs003
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
Physical Chemistry and Colloid Science
Human Nutrition (HNE)
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) randomized controlled-trial - incident alzheimers-disease - placebo-controlled trial - task-force consensus - folic-acid - methylmalonic acid - older-people - serum vitamin-b-12 - dietary-folate - holo-transcobalamin
Abstract Current recommendations on vitamin B12 intake vary from 1.4 to 3.0 µg per day and are based on the amount needed for maintenance of hematologic status or on the amount needed to compensate obligatory losses. This systematic review evaluates whether the relation between vitamin B12 intake and cognitive function should be considered for underpinning vitamin B12 recommendations in the future. The authors summarized dose-response evidence from randomized controlled trials and prospective cohort studies on the relation of vitamin B12 intake and status with cognitive function in adults and elderly people. Two randomized controlled trials and 6 cohort studies showed no association or inconsistent associations between vitamin B12 intake and cognitive function. Random-effects meta-analysis showed that serum/plasma vitamin B12 (50 pmol/L) was not associated with risk of dementia (4 cohort studies), global cognition z scores (4 cohort studies), or memory z scores (4 cohort studies). Although dose-response evidence on sensitive markers of vitamin B12 status (methylmalonic acid and holotranscobalamin) was scarce, 4 of 5 cohort studies reported significant associations with risk of dementia, Alzheimer's disease, or global cognition. Current evidence on the relation between vitamin B12 intake or status and cognitive function is not sufficient for consideration in the development of vitamin B12 recommendations. Further studies should consider the selection of sensitive markers of vitamin B12 status.
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