Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 431806
Title A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barré syndrome
Author(s) Louwen, R.; Horst-Kreft, D.; Boer, A.G. de; Graaf, L. van der; Knegt, G. de; Hamersma, M.; Heikema, A.P.; Timms, A.R.; Jacobs, B.C.; Wagenaar, J.A.; Endtz, H.P.; Oost, J. van der; Wells, J.; Nieuwenhuis, E.E.S.; Vliet, A.H. van; Willemsen, P.T.J.; Baarlen, P. van; Belkum, A. van
Source European Journal of Clinical Microbiology and Infectious Diseases 32 (2013)2. - ISSN 0934-9723 - p. 207 - 226.
Department(s) CVI Infection Biology
ID - Infectieziekten
Microbiological Laboratory
Host Microbe Interactomics
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) neisseria-meningitidis - sialic-acid - haemophilus-influenzae - pasteurella-multocida - molecular mimicry - antiganglioside antibodies - pseudomonas-aeruginosa - natural transformation - lipo-oligosaccharide - pathogenic neisseria
Abstract Guillain–Barré syndrome (GBS) is a post-infectious disease in which the human peripheral nervous system is affected after infection by specific pathogenic bacteria, including Campylobacter jejuni. GBS is suggested to be provoked by molecular mimicry between sialylated lipooligosaccharide (LOS) structures on the cell envelope of these bacteria and ganglioside epitopes on the human peripheral nerves, resulting in autoimmune-driven nerve destruction. Earlier, the C. jejuni sialyltransferase (Cst-II) was found to be linked to GBS and demonstrated to be involved in the biosynthesis of the ganglioside-like LOS structures. Apart from a role in pathogenicity, we report here that Cst-II-generated ganglioside-like LOS structures confer efficient bacteriophage resistance in C. jejuni. By bioinformatic analysis, it is revealed that the presence of sialyltransferases in C. jejuni and other potential GBS-related pathogens correlated significantly with the apparent degeneration of an alternative anti-virus system: type II Clusters of Regularly Interspaced Short Palindromic Repeat and associated genes (CRISPR-Cas). Molecular analysis of the C. jejuni CRISPR-Cas system confirmed the bioinformatic investigation. CRISPR degeneration and mutations in the cas genes cas2, cas1 and csn1 were found to correlate with Cst-II sialyltransferase presence (p¿
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